Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts

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Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts

Madsen, Ida E.H. (author): National Research Centre for the Working Environment, Copenhagen, Denmark,Department of Epidemiology and Public Health, University College London, London, United Kingdom

Hannerz, Harald (author): Federal Institute for Occupational Safety and Health BAuA, Berlin, Germany,The Danish National Centre for Social Research, Copenhagen, DK-1052, Denmark,Stress Research Institute, Stockholm University, Stockholm, Sweden

Theorell, Töres (author): Karolinska Institutet,Stockholms universitet,Stressforskningsinstitutet

Magnusson Hanson, Linda L. (author): Stockholms universitet,Stressforskningsinstitutet

Ahola, Kirsi (author): Finnish Institute of Occupational Health, Helsinki, Finland

Alfredsson, Lars (author): Karolinska Institutet

Battt, G. David (author): Department of Epidemiology and Public Health, University College London, London, United Kingdom

Bjorner, Jakob B. (author): National Research Centre for the Working Environment, Copenhagen, Denmark

Borritz, Marianne (author): Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark

Burr, Hermann (author)

Dragano, Nico (author): Department of Medical Sociology, University of Düsseldorf, Düsseldorf, Germany

Ferrie, Jane E. (author): Department of Epidemiology and Public Health, University College London, London, United Kingdom

Hamer, Mark (author)

Westerholm, Peter J M (author): Uppsala universitet,Arbets- och miljömedicin

Knutsson, Anders (author): Mittuniversitetet,Avdelningen för hälsovetenskap

Koskenvuo, Markku (author): Department of Public Health, University of Helsinki, Helsinki, Finland

Koskinen, Aki (author): Finnish Institute of Occupational Health, Helsinki, Finland

Leineweber, Constanze (author): Stockholms universitet,Stressforskningsinstitutet

Nielsen, Martin L. (author): Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, Copenhagen, Denmark

Nordin, Maria (author): Umeå universitet,Yrkes- och miljömedicin,Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden

Oksanen, Tuula (author): Finnish Institute of Occupational Health, Helsinki, Finland

Pejtersen, Jan H. (author)

Pentti, Jaana (author): Finnish Institute of Occupational Health, Helsinki, Finland

Salo, Paula (author): Department of Epidemiology and Public Health, University College London, London, United Kingdom

Singh-Manoux, Archana (author): Department of Epidemiology and Public Health, University College London, London, United Kingdom

Suominen, Sakari (author): Folkhälsan Research Center, Helsinki, Finland,Finnish Institute of Occupational Health, Helsinki, Finland

Theorell, Töres (author)

Toppinen-Tanner, Salla (author)

Vahtera, Jussi (author): Finnish Institute of Occupational Health, Helsinki, Finland

Väänänen, Ari (author): Finnish Institute of Occupational Health, Helsinki, Finland

Westerholm, Peter J. M. (author)

Westerlund, Hugo (author): Uppsala universitet,Stockholms universitet,Stressforskningsinstitutet,Arbets- och miljömedicin,Eva Vingård

Fransson, Eleonor (author): Jönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. ADULT

Heikkilä, Katriina (author): Finnish Institute of Occupational Health, Helsinki, Finland

Virtanen, Marianna (author): Finnish Institute of Occupational Health, Helsinki, Finland

Rugulies, Reiner (author): National Research Centre for the Working Environment, Copenhagen, Denmark

Kivimäki, Mika (author): Finnish Institute of Occupational Health, Helsinki, Finland

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(creator_code:org_t)

2014-02-26
2014
English.
In: F1000 Research. - : F1000 Research Ltd. - 2046-1402. ; 2

Related links:: https://doi.org/10.1...; show more...; https://umu.diva-por... (primary) (Raw object); https://f1000researc...; https://miun.diva-po... (primary) (Raw object); https://hj.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; https://urn.kb.se/re...; https://urn.kb.se/re...; https://urn.kb.se/re...; http://kipublication...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

Background: Previous studies have shown that gainfully employed individuals with high work demands and low control at work (denoted "job strain") are at increased risk of common mental disorders, including depression. Most existing studies have, however, measured depression using self-rated symptom scales that do not necessarily correspond to clinically diagnosed depression. In addition, a meta-analysis from 2008 indicated publication bias in the field.Methods: This study protocol describes the planned design and analyses of an individual participant data meta-analysis, to examine whether job strain is associated with an increased risk of clinically diagnosed unipolar depression based on hospital treatment registers. The study will be based on data from approximately 120,000 individuals who participated in 14 studies on work environment and health in 4 European countries. The self-reported working conditions data will be merged with national registers on psychiatric hospital treatment, primarily hospital admissions. Study-specific risk estimates for the association between job strain and depression will be calculated using Cox regressions. The study-specific risk estimates will be pooled using random effects meta-analysis.Discussion: The planned analyses will help clarify whether job strain is associated with an increased risk of clinically diagnosed unipolar depression. As the analysis is based on pre-planned study protocols and an individual participant data meta-analysis, the pooled risk estimates will not be influenced by selective reporting and publication bias. However, the results of the planned study may only pertain to severe cases of unipolar depression, because of the outcome measure applied.

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Occupational Hea ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Health Sciences; and Public Health Gl ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Psychiatry

Articles in the publication: F1000 Research

By the university: Umeå University; Mid Sweden University; Jönköping University; Stockholm University; Uppsala University; Karolinska Institutet

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Study protocol for examining job strain as a risk factor for severe unipolar depression in an individual participant meta-analysis of 14 European cohorts

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